The Prediction of the Bisoprolol Effectiveness in Patients with Stable Coronary Artery Disease with Post-Infarction Cardiosclerosis

The article shows the benefits of treatment with bisoprolol in achieving optimal heart rate at rest (55-60 per 1 minute) and identifies the prediction markers of its achievement in patients with stable coronary artery disease with post-infarction cardiosclerosis, taking into account clinical and genetic data: physical examination, 24-hour ECG monitoring, 5-minute study of heart rate variability, Arg389Gly polymorphism of the ADRB1 gene. The article proved that when a heart rate of 55-60 in 1 minute is reached, the antianginal effect of bisoprolol is expressed better, the markers of the prognosis in the achievement of this heart rate are determined.