[Detection of B-cell marker of rheumatism using monoclonal antibodies D8/17 in the families of patients with rheumatism].

: To study hereditary disposition for rheumatism (R) 141 persons including 26 probands of patients with R, 79 relatives and also 12 newborns of mothers with R were examined. The carriage of the B-cell markers was studied by means of antibodies D8/17. The B-cell marker was revealed in 96.2 per cent probands and in 41.4 per cent relatives. Among the female relatives with R the B-cell marker carriage was revealed in 51.2 per cent, among the male relatives in 25.9 per cent. A high carriage of the given marker in children and young people aged 4-34 born of mothers with R was noted (66.7 per cent). Among the newborn no carriers of the B-cell marker were detected. A conclusion has been made of the participation of the B-cell marker in the formation of hereditary predisposition for R.