Resistance to Dual Nucleoside Reverse-Transcriptase Inhibitors in Children Infected with HIV Clade A/E

The prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) mutations was determined among 95 human immunodeficiency virus–infected Thai children who were treated with dual nucleoside reverse-transcriptase inhibitors. Almost all children had resistance to at least 1 NRTI and approximately half of the children had resistance to multiple NRTIs. Cross-resistance to stavudine and azidothymidine was universal. (authors)