Fabrication of poly-sulfosalicylic acid film decorated pure carbon fiber as electrochemical sensing platform for detection of theophylline

Abstract In this work, we integrated the superiority of good conductivity, large surface area of carbon fibers and the catalytic property, good biocompatibility of polymer sulfosalicylic acid to construct a novel electrochemical sensor to detect theophylline in drug analysis. The morphology of nanocomposite was characterized by scanning electron microscopy (SEM). The polymerization between monomers was observed by Fourier transform infrared spectroscopy (FTIR). The composite between carbon material and polymer was verified by Raman spectrum. Under the optimal experimental conditions, the concentration of theophylline (0.6∼137 μM) and the peak current value revealed a good linear relationship and the limit of detection as low as 0.2 μM. In addition, the proposed sensor exhibits repeatability, stability and ease of selectivity.