Agglomeration of Antihypertensive Drug by Spherical Crystallization Method

Hypertension is a key adaptable cardiovascular risk factor. There are several types of drugs that can be used in the management of hypertension. But the perfect treatment strategy remains uncertain for such a common and treatable disease. Various approaches applied for solubility and bioavailability improvement of poorly water-soluble drugs solid dispersion is one of the most successful method for increasing the drug dissolution rate of the drug. Although these techniques have commonly been used to increase dissolution rate of the drug, there are practical limitations with these techniques, the desired bioavailability enhancement may not always be achieved. In the current work, it was concentrated on improvement of the solubility of candesartan drug by spherical crystallization method. Findings were concluded that spherical agglomerates of candesartan prepared using spherical crystallization technique, showed significant improvement in flowability, compatibility, solubility and dissolution rate of the candesartan compared with pure candesartan. Keywords: Hypertension, Candesartan, Spherical