Analysis of prognostic risk factors for pediatric acute leukemia with fungemia
2014
Objective To investigate the epidemiology of fungemia and provide evidence for clinical therapy.Methods A retrospective survey was conducted with 42 cases of fungemia in our hospital from Jan 2002 to Jan 2011.Results Forty cases candida fungemia accounted for 95.2% in 42 fugemia.The main pathogen agent was non-Candida albicans in candida fungemia,which were candida albicans(14.3%),candida parapsilosis (38.1%),candida glabrata (35.7 %),candida tropicalis (2.4%).Eleven uneffecfive cases accounted for 26.2%.Multiple-factor analysis showed that neutropenia time > 7 days,antibiotic using time > 7 days and fungal infection history correlated with bad prognosis.Our study also showed that chemotherapy regiments including hormone、combining with other organs fungal infection and non-Candida albicans were risk factors of bad prognosis.Conclusion The main pathogen agent of fungimia is candida,especially non-Candida albicans.Neutropenia time > 7 days,antibiotic using time > 7 days and fungal infection history correlate with poor prognosis.
Key words:
Acute leukemia; Fungemia; Prognosis; Children
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