Intra-hepatic lipiodol I 131 combined with oxaliplatin, infusional FUDR, leucovorin in hepatocarcinoma and hepatic metastasis
2004
4133 Background: We conducted a pilot study with L131 internal hepatic radiation combined with IA OHP, infusion FUDR and LV in 19 AHC and 20 HM pts, to assess feasibility, response rate, symptom relief, TTP and 1-year OS. Methods: Median age was 60 yo (20 - 76), 32 pts were male. All pts had predominant hepatic disease and symptomatic progression prior to inclusion. Portal vein thrombosis was documented in 3 pts. KPS was 70% in 4 pts and ≥ 80% in 35 pts. All HM and 10 out of 19 AHC pts have had prior treatment (range: 1–9). Out of 19 AHC pts, 12 were Child-Pugh A, 7 were B and 2 were C. Out of 20 HM, 14 were colorectal tumors. All pts were assigned to receive only one treatment. However, re-treatment was allowed after documented liver progression by CT or MRI in responders or to reach a tumor radiation dose ≥120 Gy. Therapy was a single L131 intra-hepatic infusion dose followed by OHP 100 mg/m2 IA over 2h on D1, and FUDR 60 mg/m2/d + LV 15 mg/m2/d IA by 96h infusion (D1–4). G-CSF SC was given from D5–15. ...
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI