Bilateral adrenal enlargement with an unexpected diagnosis

Abstract A 78-year-old man, previously treated for prostate and colorectal cancer, was admitted to the hospital because of persistent fever. He was found to have bilateral large adrenal masses and adrenal insufficiency. Primary large B-cell lymphoma was proven by aspiration biopsy of the left adrenal gland. On presentation, no evidence of lymphoma outside the adrenal glands was found. The patient died before treatment could be initiated. The autopsy report is discussed briefly. Primary adrenal lymphoma is a rare entity and should be considered in a patient with bilateral adrenal masses without nodular involvement.