Polytrifluorostyrene-coated silica as a packing for column liquid chromatography

A reversed-phase hydrolytically stable packing material prepared by chemisorption of a trifluorostyrene-containing copolymer on to the surface of porous silica was tested by high-performance liquid chromatography of various aromatic compounds. It was found that the polytrifluorostyrene (PTFS) phase has an intermediate adsorption activity between those of polytetrafluoroethylene and polystyrene phases. A high selectivity of PTFS-coated silica in the separation of haloaryl compounds was observed. Wide-pore silica coated with PTFS was found to give an efficient resolution of peptides and proteins.