Thermal, Spectral, Antibacterial and Antioxidant Studies on Inclusion Complexes of 2-(Benzothiazolyl-2’)hydrazono-3-phenyl 5-arylidene- 4- Thiazolidinone derivatives with β-cyclodextrin

Thiazolidinone derivatives are very good pharamacophore showing a wide range of pharmacological activities. But poor solubility of these drugs in aqueous medium is a major drawback towards their bio-accessibility. Hence, the solubility of these compounds can be enhanced by forming the inclusion complexes with a suitable oligosachhride i.e. s-cyclodextrin. In this context, some compounds of 2-(Benzothiazolyl-2’)hydrazono-3-phenyl -5-arylidene- 4- Thiazolidinone derivatives has been prepared starting from 2-Hydrazino benzothiazole. The solubility and bioavailability character of each dry synthesized compound can be enhanced by caging it in the core of s-cyclodextrin. Through physical, thermal and spectral analysis the formation of inclusion complex is established. The biological active nature of compounds and their inclusion complex is studied and it revealed that the latter is performed better than the former compound.