Synthesis and utilization of optically active α-aminophosphonate derivatives by Kabachnik-Fields reaction

Abstract ( S ) - α - Phenylethylamine was used in the microwave-assisted Kabachnik-Fields condensation with paraformaldehyde and >P(O)H species, such as dialkyl phosphites, ethyl phenyl- H -phosphinate and diphenylphosphine oxide to provide optically active α-aminophosphonates, α-aminophosphinate and α-aminophosphine oxide, or using a two equivalent quantity of paraformaldehyde and (RO) 2 P(O)H or Ph 2 P(O)H, bis(phosphonomethyl)amines and bis(phosphinoylmethyl)amine, respectively. The bis(phosphinoylmethyl)amine served as a precursor for an optically active bidentate P-ligand in the synthesis of a chiral platinum complex.