Study on pharmacoknetics of modafinil in rat

2004 
OBJECTIVE To study the pharmacokinetics behavior of modafinil in rat.METHODS The concentration of modafinil in serum was determined by HPLC following a single oral dose. The pharmacokinetics parameters were fitted by 3P87 program. The steady state concentrations of modafinil in blood were also determined by HPLC.RESULTS The RSD of intra day and inter day were less than 3%.The serum concentration curves fitted the two compartment model. The main parameters were as follows: T 1/2α was ( 0.48 ± 0.09) h , T 1/2β was ( 3.55 ± 0.27) h , T max was ( 0.79 ± 0.06) h , C max was ( 3.53 ± 0.05) mg ·L -1 ,AUC 0~∞ was ( 14.32 ± 0.30) mg .The actual value and expectant result was anastomotic elementally. CONCLUSIONS The distribution of modafinil in rats is fast, the elimination is slow.
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