The laboratory diagnostics of syphilis: yesterday, today, tomorrow

The article covers issues related to the development of laboratory methods used for the diagnostic of syphilitic infection in the historical aspect as well as for the nearest and remote future. Priorities of the application of several diagnostic methods have been highlighted depending on the stage and form of syphilis, on the performed specific treatment and the contingent of examined patients. The authors give recommendations for its use reflected in modern Russian and foreign manuals and standards of syphilis diagnostics. Laboratory methods such as immunochemiluminescence assay, хМАР-technology and aspects of their clinical application are specially highlighted. The authors provide data on applied methods of molecular typing of Т. pallidum and detection of genetic determinants of the resistance of the syphilis pathogen to antimicrobial substances.