Improved GPCR Ligands Based on Genetically Impossible Nanobody-Peptide Fusions

Ross W. Cheloha,Fabian A. Fischer,Andrew W. Woodham,Eileen J. Daley,Naomi Suminski,ThomasJ. Gardella,Hidde L. Ploegh

Improved GPCR Ligands Based on Genetically Impossible Nanobody-Peptide Fusions

2019

Ross W. Cheloha
Fabian A. Fischer
Andrew W. Woodham
Eileen J. Daley
Naomi Suminski
ThomasJ. Gardella
Hidde L. Ploegh

Here we describe a new method for improving signalling potency and selectivity for suboptimal GPCR ligands through conjugation with receptor-targeting nanobodies

Keywords:

Peptide
Chemistry
G protein-coupled receptor
Biochemistry

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations