Expression of urokinase-type plasminogen activator in medulloblastoma of children

AIM To study expression and clinical significance of urokinase type plasminogen activator (uPA) in medul loblastoma of children. METHODS Expression of uPA in 84 cases of pathologically confirmatory and followed up medulloblastoma of children (46 males, 38 females, aged from 6 to 12 years) was detected with labelled strepatavidin biotin (LSAB). The cases were divided into 3 groups according to survival period of 3, 5, 10 a respectively. Cox regression analysis was used. RESULTS Expression positive rate of uPA was 52% (44/84), and were 71%, 41%, and 20% in group A, B, and C respectively ( P 0.01). Cox regression showed that uPA was in independent prognostic factor affecting survival and it had close negative correlation with the prognosis. CONCLUSION Expression level of uPA was closely related to predicting prognosis of medulloblastoma in children.