CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF VARIOUS EXTRACTS OF CORRIGIOLA TELEPHIIFOLIA POURR.

Background: The use of natural products as anticancer and antioxidant agents has a long history. Several chemotherapy drugs were isolated from medicinal plants. Objective: The present study was aimed to provide information on cytotoxic and antioxidant activity of cyclohexane, dichloromethane and methanol extracts of Corrigiola telephiifolia. Materials and method: The plant roots were dried, powdered and extracted successively by cold maceration with: cyclohexane, dichloromethane and methanol for 48h. All extracts have been assessed for antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical and cytotoxic activity against murine colon adenocarcinoma CT-26 and melanoma cell lines WM-266. Results: The dichloromethane extract exhibited potent cytotoxicity with an IC50 of 80 ± 4.56 for CT-26 cells and 70 ± 6.1 µg/ml for WM-266 cells. The extracts exhibited moderate antioxidant activity with IC50 value of 10.53 µg/ml of the dichloromethane extract compared to the IC50 value of 4.71 ± 0.83 µg/ml as shown by the reference antioxidant Trolox. Conclusion: The potential activity of Corrigiola telephiifolia root extract may due to their phytochemical constituents, these species could be considered as potential sources of anticancer compounds. Further studies are necessary for chemical characterization of the active principles and more extensive biological evaluations.