Alternative splicing of SYK regulates mitosis and cell survival

Although splice isoforms have been observed to change in cancerous cells, the effect of these changes has not always been clear. Using antisense technology, cancer-associated isoforms have now been manipulated in cell lines. The results indicate that shifting splicing patterns of SYK can contribute to cell-cycle changes and anchorage-independent growth and that this change is also triggered by EGF signaling.