Endothelin-1 (1–31) Induces Spreading Depolarization in Rats

Background: The vasoconstrictor endothelin-1(1–21) (ET-1) seems to induce cerebral vasospasm after aneurismal subarachnoid hemorrhage (aSAH). Moreover, ET-1 causes spreading depolarization (SD) via vasoconstriction/ischemia. ET-1(1–31) is an alternate metabolic intermediate in the generation of ET-1. Our aim was to investigate whether endothelin-1(1–31) causes SD in a similar fashion to ET-1.