Stereoselective approach to (2R,3S)- and (2R,3R)-1,2-(cyclohexylidenedioxy)hept-6-en-3-ol by microbial reduction
2012
Abstract Among twelve incubated whole-cell yeast strains, two were found to selectively reduce ( R )-1,2-(cyclohexylidenedioxy)hept-6-en-3-one, which was derived from d -mannitol. Pichia minuta JCM 3622 and Rhodotorula mucilaginosa NBRC 0889 afforded (2 R ,3 S )-form (97% diastereomeric purity) and (2 R ,3 R )-form (89% diastereomeric purity) of 1,2-(cyclohexylidenedioxy)hept-6-en-3-ols, respectively. As discussed above, the complementary yeast-mediated reduction provided the two diastereomeric glycerol derivatives in high enantiomeric excess.
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