687 SERUM IP-10 LEVEL ASSOCIATED WITH HEPATOCELLULAR CARCINOMA DEVELOPMENT IN PATIENTS WITH CHRONIC HEPATITIS B

correlation remained significant in patients with early-stage HCC or with normal serum AFP level. Multivariate analysis indicated that LARP1 expression might be an independent prognostic indicator of the survival of patients with HCC. Furthermore, we found that ectopic expression of LARP1 induced, while silencing LARP1 inhibited, cell invasion and anchorage-independent growth ability. Moreover, we demonstrated that the upregulation of LARP1 could reduce the expression of e-cadherin and induce the expression of fibronectin. Conclusions: Our findings suggest that the LARP1 protein is a valuable marker of HCC progression and may represent a novel prognostic biomarker and therapeutic target for the disease.