MR MORPHOMERY OF THE HIPPOCAMPUS IN NORMAL VOLUNTEERS AND PATIENTS WITH PSYHOTIC DISORDERS DISEASE

Role of limbic system, first of all, hippocampal formation, is carefully analyzed in literature because of its involvement in different psychiatric diseases. Results are contradictory, may be because of insufficient data of normal volumes of structures involving in cognitive and affective functioning of the brain. Hippocampus is very complex organized structure consisting of different subfields and subregions which probably differently changes in different psychiatric diseases. Aim of our study was to analyzed changes in volumes of the whole hippocampus, its subregions and subfields in different psychiatric diseases. In our study we have analyzed MRI morphometry of hippocampal formation in healthy volunteers, patients with Alzheimerdisease (AD) in early stage, vascular dementia (VD), depression based on medical literatureandourexperience. Patients were divided on 4 groups: 10 patients with early Alzheimer disease, 10 normal volunteers, 10 patients with vascular dementia and 10 patients with depression. We have determined method of definition and volume evaluation of different hippocampal subfields. We find difference in the volumes of CA3, molecular stratum and fascia dentatain early stage of AD; in the volume of hippocampal tail, molecular stratum of fascia dentataand CA3 in patients with VD; in molecular stratum of fasciadentata, fimbria and CA3 in patients with depression because of role of these fields in coordination of hippocampal activity.