Potential Role of In vitro-In vivo Correlations (IVIVC) for the Development of Plant Derived Anticancer Drugs.

BACKGROUND Conventional medicines, along with herbal formulations of Chinese, serves as the primary source and hub of active new drugs where the initial research concentrate in the extraction and isolation of bioactive lead com-pound(s) to treat several diseases largely for cancer. Plant-derived natural products and their analogs reveal a significant source of several clinically useful anticancer agents. Herbs and herbal derived active compounds play an unavoidable role in the treatment, drug discovery and delivery for decades,as evidenced by numerous existing marked drugs and various cancer-related molecular targets in clinical development. OBJECTIVE Solubility, resistance and metabolic limitations of the drugcan be overcome by suitable molecular modifications; Due to enhancements in tumor targeting technology, some agents which failed in earlier clinical studies are also stimulating renewed interest. In this connection, In Vitro In Vivo Correlation (IVIVC) plays an important role in the development of dosage forms in the field of pharmaceutical technology. CONCLUSION IVIVC tool fastens and improves the drug development process and product quality, which is also utilized in internal control for scale-up, to improve formulations and alternativeproduction processes. Most importantly, this IVIVC tool lessens the quantity of human studies during new pharmaceuticals developments. In this review, we would like to grab the attention of readers to the importance and significance of IVIVC for natural products of anticancer drugs examples such as Docetaxel, Etoposide phosphate, 6-Gingerol, Capsaicin, etc.