Relationship between glycated albumin and glycated hemoglobin according to glucose tolerance status: A multicenter study

Abstract Aims To determine the relationship between glycated albumin (GA) and glycated hemoglobin (HbA1c) and to explore the association of glycated albumin/glycated hemoglobin (GA/HbA1c) ratio with glucose indices in Chinese subjects with varying glucose tolerance status. Methods This hospital-based, cross-sectional study involved 953 participants without known diabetes from 11 centers in China. Oral glucose tolerance test (OGTT) was used to identify three groups of subjects: normal glucose regulation ( n  = 194), impaired glucose regulation ( n  = 303) and newly diagnosed type 2 diabetes group ( n  = 456). The GA, HbA1c and GA/HbA1c ratio were tested. Results GA was positively correlated with HbA1c ( r  = 0.832, P r  = 0.824, P R 2  = 0.692, P P I 30 /Δ G 30 (all, P β  = 0.221, P β  = −0.114, P  = 0.008) were associated with elevated GA/HbA1c ratio by multiple linear regression (adjusted R 2  = 0.045). Conclusions The relationship between GA and HbA1c was strong. The GA/HbA1c ratio was related to acute postprandial glucose fluctuation and BMI level.