MP13-20 COMBINATION OF 68GA-PSMA PET/CT AND MULTIPARAMETER MRI IMPROVES THE DETECTION OF CLINICALLY SIGNIFICANT PROSTATE CANCER: A LESION BY LESION ANALYSIS

INTRODUCTION AND OBJECTIVES:Multiparametric magnetic resonance imaging (mpMRI) misses the diagnosis of part of clinically significant prostate cancer (csPCa). 68Ga-labeled PSMA positron emission tomography (68Ga-PSMA PET/CT) has been recently investigated as a first line diagnostic tool. This study was designed to explore whether 68Ga-PSMA PET/CT or the combination of mpMRI and 68Ga-PSMA PET/CT (MRI/PET) can improve the detection of csPCa.METHODS:We retrospectively enrolled 54 patients who underwent both mpMRI and 68Ga-PSMA PET/CT before radical prostatectomy. Regions of interest (ROI) on imaging from mpMRI, 68Ga-PSMA PET/CT and pathology were marked. A lesion was defined when ROI was marked in the same location on continuous imaging at any of the imaging setting. All lesions were recorded by PI-RADS scoring, Mi-ES scoring and pathology results and analyzed. The diagnostic performance was analyzed by receiver operating characteristics (ROC) analysis. Specific improvement for lesions with different PI-RADS...