The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway.

Chunping Yu1,2,y, Zhiling Zhang1,3,y, Wenting Liao4,y, Xiaohui Zhao, Liping Liu, Yanheng Wu, Zhuowei Liu, Yonghong Li, Yi Zhong, Kun Chen, Jun Li, Fangjian Zhou and Libing Song State Key Laboratory of Oncology in Southern China, Department of Experimental Research and Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou 510060, Department of Pathology, Southern Medical University, Guangzhou 510515, Department of Medical Image, First Affiliated Hospital of Jinan University, Guangzhou 510632, Department of Neurosurgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080 and Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510000, People’s Republic of China