Effect of Verapamil Enantiomers and Metabolites on Cardiac K+ Channels Expressed in Xenopus Oocytes

Siegfried Waldegger,G. Niemeyer,K. Mörike,Carsten A. Wagner,Hartmut Suessbrich,Andreas E. Busch,Florian Lang,M. Eichelbaum

Effect of Verapamil Enantiomers and Metabolites on Cardiac K+ Channels Expressed in Xenopus Oocytes

1999

Siegfried Waldegger
G. Niemeyer
K. Mörike
Carsten A. Wagner
Hartmut Suessbrich
Andreas E. Busch
Florian Lang
M. Eichelbaum

The effect of verapamil and its enantiomers and metabolites on cardiac action potential repolarizing potassium channels was tested. For this purpose, the potassium channels Kv1.1, Kv1.5, Kir2.1, and H

Keywords:

Potassium channel
KvLQT1
Afterdepolarization
Voltage clamp
Xenopus
Calcium channel blocker
Cardiac action potential
Biochemistry
Pharmacology
Biology
Verapamil
hERG
Enantiomer

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