Synthesis of the C1–C23 Fragment of the Archazolids and Evidence for V-ATPase but not COX Inhibitory Activity

A convergent synthesis of a C 1 –C 23 fragment of the archa­zolids has been completed based on a high-yielding Stille coupling to construct the substituted Z , Z , E -conjugated triene. After removal of the protecting groups, the resulting tetrol exhibited evidence for inhibition of the vacuolar-type ATPase (V-ATPase) but not cyclooxygenase (COX) inhibitory activity.