Regional Cerebral Blood Flow in Adult Patients with Moyamoya Disease Presenting with Ischemic Symptom

We studied regional cerebral blood flow (r-CBF) by the Patlak plot method with 99mTc-SPECT in 5 adult patients with moyamoya disease presenting with ischemic symptoms. The mean values of r-CBF at rest of ACA, MCA and PCA territories were 38.0±1.9 (SD), 38.5±3.7 and 38.0±1.9 ml/100 g/min, respectively. The increase in r-CBF after administration of acetazolamide was 4.8, 5.8 and 12.3 ml/100 g/min, respectively. After bilateral double STA-MCA anastomosis with encephalo-myo-arterio-synangiosis, the r-CBFs at rest markedly improved, whereas those after administration of acetazolamide showed no significant change.