A phase I study of prolonged infusion of triapine in combination with a fixed-dose rate of gemcitabine in patients with advanced solid tumors.
2010
2602 Background: Triapine (T), an inhibitor of ribonucleotide reductase, enhances the activity of gemcitabine (G), and the synergism is most evident when the pre-exposure time to T is prolonged. In...
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