Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

Atsushi Obata,Tomohiko Kimura,Yoshiyuki Obata,Masashi Shimoda,Tomoe Kinoshita,Kenji Kohara,Seizo Okauchi,Hidenori Hirukawa,Shinji Kamei,Shuhei Nakanishi,Tomoatsu Mune,Kohei Kaku,Hideaki Kaneto

Vascular endothelial PDPK1 plays a pivotal role in the maintenance of pancreatic beta cell mass and function in adult male mice

2019

Atsushi Obata
Tomohiko Kimura
Yoshiyuki Obata
Masashi Shimoda
Tomoe Kinoshita
Kenji Kohara
Seizo Okauchi
Hidenori Hirukawa
Shinji Kamei
Shuhei Nakanishi
Tomoatsu Mune
Kohei Kaku
Hideaki Kaneto

Aims/hypothesis The aim of this study was to elucidate the impact of 3′-phosphoinositide-dependent protein kinase-1 (PDPK1) in vascular endothelial cells on the maintenance of pancreatic beta cell mass and function.

Keywords:

Beta cell
Endocrinology
Internal medicine
Diabetes mellitus
Biology
Vascular endothelial growth factor A
Insulin
Islet
ETS1
Knockout mouse
PDX1
Incretin

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