Abstract 10231: Parp1-Pkm2 Axis Mediates Right Ventricular Failure Associated with Pulmonary Arterial Hypertension

Tsukasa Shimauchi,Wen-Hui Wu,Yann Grobs,Junichi Omura,Eve Tremblay,Sandra Martineau,Tetsuro Yokokawa,Kana Shimauchi,Valérie Nadeau,Sandra Breuils Bonnet,Mark Orcholski,Roxane Paulin,François Potus,Olivier Boucherat,Steeve Provencher,Sébastien Bonnet

Abstract 10231: Parp1-Pkm2 Axis Mediates Right Ventricular Failure Associated with Pulmonary Arterial Hypertension

2021

Tsukasa Shimauchi
Wen-Hui Wu
Yann Grobs
Junichi Omura
Eve Tremblay
Sandra Martineau
Tetsuro Yokokawa
Kana Shimauchi
Valérie Nadeau
Sandra Breuils Bonnet
Mark Orcholski
Roxane Paulin
François Potus
Olivier Boucherat
Steeve Provencher
Sébastien Bonnet

Introduction: Right ventricular (RV) function is the poor prognosis factor in pulmonary arterial hypertension (PAH) patients. Inflammation, oxidative DNA damage, and glycolysis are key triggering p...

Keywords:

Inflammation
Cardiology
PKM2
Pulmonary hypertension
PARP1
poor prognosis
Internal medicine
Glycolysis
oxidative dna damage
Right ventricular failure
Medicine

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