Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).

Katherine Sanchez,Maritza Martel,Shu-Ching Chang,Yaping Wu,Zhaoyu Sun,Richard Nyberg,William L. Redmond,Joanna Pucilowska,Shaghayegh Aliabadi-Wahle,James H. Imatani,Alison Katherine Conlin,Brady Bernard,Monil Shah,Dottie Wadell,Deborah R. Laxague,Lu Wen,Qiao Li,Gregory T. Wolf,Walter J. Urba,David B. Page

Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).

2019

e12070Background: In triple negative breast cancer (TNBC), anti-PD-L1 is associated with gains in overall survival, however only in tumors with > 1% PD-L1+ ICs. Locoregional cytokine therapy is bei...

Keywords:

PD-L1
Breast cancer
Cell
Immune system
Triple-negative breast cancer
Immunotherapy
Pathology
Oncology
Cytokine Therapy
Immunohistochemistry
Internal medicine
Medicine
pd l1 expression

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