Diastereoselective synthesis of a core fragment of ritonavir and lopinavir

Arnab Roy,Lekkala Amarnath Reddy,Namrata Dwivedi,Jyothirmayi Naram,Rodda Swapna,Golla China Malakondaiah,Mylavarpu Ravikumar,Dinesh S. Bhalerao,Taduri Bhanu Pratap,Padi Pratap Reddy,Apurba Bhattacharya,Rakeshwar Bandichhor

Diastereoselective synthesis of a core fragment of ritonavir and lopinavir

2011

Arnab Roy
Lekkala Amarnath Reddy
Namrata Dwivedi
Jyothirmayi Naram
Rodda Swapna
Golla China Malakondaiah
Mylavarpu Ravikumar
Dinesh S. Bhalerao
Taduri Bhanu Pratap
Padi Pratap Reddy
Apurba Bhattacharya
Rakeshwar Bandichhor

Abstract A novel approach to the synthesis of Boc-core, a key starting material for ritonavir and lopinavir involving an unprecedented diastereoselective nitroaldol reaction on β-amino aldehyde is disclosed.

Keywords:

Core fragment
Aldehyde
Ritonavir
HIV Protease Inhibitor
Lopinavir
Nitroaldol reaction
Photochemistry
Stereochemistry
Chemistry

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