Lipoxygenation of Mitochondrial Membranes by Reticulocyte Lipoxygenase

There is considerable interest in the lipoxygenation of mitochondrial membranes because of the inhibitory influence this process can have on mitochondrial activities such as oxidative phosphorylation (Vladimirov et al., 1980). In addition, mitochondrial lipid peroxidation has been associated with several important pathological conditions. These include hypoxia and postischemic reperfusion (Hillered and Ernster, 1983), aging (Nohl et al., 1978), and the cytotoxicity of many chemicals as well as UV or ionizing radiation (Vladimirov et ai., 1980).