The effect of oxisuran on differential inhibition of cell-mediated immunity.

Oxisuran, 2-[(methylsulfinyl) acetyl] pyridine suppressed allogeneic skin graft rejection in rats. In PHA responses and one way mixed lymphocyte culture, suppression of cell-mediated immunity was indicated. However, little inhibition of PFCs was observed with Oxisuran, and unlike Azathioprine or Neocarzinostatin, Oxisuran did not concomitantly suppress antibody-producing system in rats. These data suggest that selective suppression of cell-mediated immunological responses by Oxisuran is possible in rats, and Oxisuran may be a better immunosuppressant for clinical organ transplantation.