Economical syntheses of 3H‐2H and 14C‐labeled ethyl acetates

Tritium and 14C-labeled isomers of ethyl acetate are excellent substrates for competitive dual-labeled radioactive isotopic measurements of β-deuterium and β-tritium isotope effects. Methods are given for preparation of the ethyl esters of acetic acid-2-3H, acetic acid-2-14C, and acetic acid-2,2-2H2-2-3H, and of the acetic acid ester of ethanol-l-14C from the least costly labeled precursors in high purity (yield 70-80%) on the mmole scale.