THE EFFECT OF ASTRAGALUS MEMBRANACEUS(FISCH) BGE. ON LIPID PEROXIDATION AND NO LEVEL OF MYOCARDIUM FROM RATS WITH DIABETIC NEPHROPATHY

Aim: To study the effect of astragalus membranaceus(Fisch)bge. on the lipid peroxidation and NO level of myocardium from rats with diabetic nephropathly.Methods: Male wistar rats were divided into five groups: ① Aormal control group,② Diabetes group,③ Diabetic nephropathy group, ④ Diabetic nephropathy group complicated with acute renal function damage,⑤ Astragalus membranaceus(Fisch)bge. treatment group. The activity of superoxide dismutase(SOD), glutathione peroxidase(GSH Px), nitric oxide synthase(NOS) and content of malondialdehyde (MDA), nitric oxide(NO) was determined biochemically from myocardial homogenate among different groups.Results: The activity of GSH Px, SOD decreased and the content of MDA, NO and NOS activity increased in each experimental group compared with control group, as was more obvious in diabetic nephropathy group with acute renal function damage, which astragalus membranaceus(Fisch)bge could improve. Conclusion: astragalus membranaceus(Fisch)bge. could protect the myocardium in diabetic nephropathy by inhibiting lipid peroxidation and decreasing the level of NO.