Mechanism of the effect of aspirin on the functional properties of thrombocytes

: As shown the inhibitory effect of aspirin administered in vivo on platelet aggregation and factor 3 release in vitro was due to the action of aspirin on the blood platelets and plasma cofactors: plasma from aspirinized rats dimished aggregability of platelets from untreated animals; plasma from untreated rats increased the aggregability and factor 3 availability of platelets from aspirinized animals.