Deep Learning in Diabetic Foot Ulcers Detection: A Comprehensive Evaluation.

There has been a substantial amount of research on computer methods and technology for the detection and recognition of diabetic foot ulcers (DFUs), but there is a lack of systematic comparisons of state-of-the-art deep learning object detection frameworks applied to this problem. With recent development and data sharing performed as part of the DFU Challenge (DFUC2020) such a comparison becomes possible: DFUC2020 provided participants with a comprehensive dataset consisting of 2,000 images for training each method and 2,000 images for testing them. The following deep learning-based algorithms are compared in this paper: Faster R-CNN; three variants of Faster R-CNN; an ensemble consisting of four models obtained using Faster R-CNN approaches; YOLOv3; YOLOv5; EfficientDet; and a new Cascade Attention Network. These deep learning methods achieved the best top 5 results in DFUC2020. For each deep learning method, this paper provides a detailed description of obtaining the model, including pre-processing, data augmentation, architecture, training and post-processing, and parameter settings. We provide a comprehensive evaluation for each method. All the methods required a data augmentation stage to increase the number of images available for training and a post-processing stage to remove false positives. The best performance is obtained by Deformable Convolution, a variant of Faster R-CNN, with a mAP of 0.6940 and an F1-Score of 0.7434. Our results show that state-of-the-art deep learning methods can detect DFU with some accuracy, but there are many challenges ahead before they can be implemented in real world settings.