Clinical study on effect of JINTIANGE capsules for treatment of primary osteoporosis

Objective To investigate the effect of JINTIANGE capsules in treating primary osteoporosis.Methods Totally,660 patients with primary osteoporosis were divided into 5 groups randomly and a multi-center randomize double-blind controlled trial was couducted.Different Chinese medicines were given to the 5 groups:Tiger 1 group: bionic tiger bone pill;Tiger 2 group: natural tiger bone pill;Tiger 3 group: JINTIANGE Capsules;Tiger 4 group: natural tiger bone capsule;Open group:open for Tiger 1 group.All of the groups were treated orally for 3 months with 3 capsules/pills,tid.Dual energy X-ray absorptionmetry(DEXA) scanner was used for measuring BMD at spine(L_ 2-4) and hip.The blood Ca 2+,P concentration and alkali phosphatase activity were also detected.Results (1)The effective rate and total effective rate were 29.17 and 88.34% for Tiger 1 group,30.83% and 84.16% in Tiger 2 group,33.33 and 80.83% in Tiger 3 group and 27.50 and 80.83% in Tiger 4 group.The efficacy among the 4 groups showed no significant difference(P0.05).(2)The score of symptom and physical signs in all of the groups showed significant decrease after 3 months treatment(P0.001) indicating significant change in physical signs and symptoms after treatment.(3)The BMD measurement showed that all of the Chinese medicines could enhance spine and hip bone density without significant difference among all groups.(4)The efficacy difference between Tiger 1 and Tiger 3 were irrelevant(P0.05) to age,sex,illness and duration of disease.Conclusions JINTIANGE Capsules has the same efficacy on primary osteoporosis as the natural tiger bone pill and capsules.JINTIANGE Capsules will be the ideal Chinese medication for primary osteoporosis patients to enhance bone strength.The bionic tiger bone power would be possible to substitute the natural tiger bone as an important ingredient in TCM for treatment of bone related diseases in the future.