Clinical analysis of mixedacute leukemia

：Objective To analyze theclinical and biological features of mixed acute leukemia(MAL).Methods Bone marrowspecimens of 38 MAL patients were evaluated to prove the diagnosis and the classificationby morphoiogic,immunologic examinations.These patients were treated with protocolssuitable for both acute myeloid leukemia(AML)and acute lymphoblastic leukemia(ALL).ResultsAll MAL patients had a leukemia syndrome.Morphologically,the subtypes of M1,M2 and M5 werepredominant in AML,as L2 Was in ALL.Immunologically,coexpression of myeloid and B lineageassociated antigens was predominant,about 68.4%;cytogenetically,Ph chromosome was observedin 33.3%(5/15)of MAL patients,and immunophenotype was B-M;1 Ph chromosome(+)MALpatient,fusion gene bcr-abl 190(+)and immunophenotype was B-M.In 38 cases,32 patientsreceived chemotherapy.The complete remission rate was 28.1%(9/32).CR of.normal karyotypewas significantly higher than that of abnormal ones.Conclusion Patients with MAL haveunique biological features and the complete remission rate was low and the prognosis waspoor. Key words: Leukemia,mixed-cell; Immunophenotyping; Prognosis