Evaluation of some biological aspects of the presence of abrasive silica and thickening silica in basic formulations of dentifrices

The aim of this study was to evaluate some biological characteristics and toxicity of basic formulations of dentifrices containing such substances, and to compare them with two existing products in market which also contains silic in their formulations. In this way, it was evaluated some biological parameters: weight of the animals, oral toxicity, hematological parameters, urinary analysis, and histological evaluation. The thrombocytes were also statistically at normal levels. The glutamate-pyruvate transaminase (TGP) showed normal aspect in 5 of the tested groups, as in control. Meanwhile, the oxalacetic transaminase (AST) in one group had a small increase in the control group. Regarding urine, in exception the rats of one group, the rats of the 4 other experimental groups showed leukocytosis urinary statistically higher than the control group. The histological evaluation of the animals showed that specimens from liver, stomach, kidney and submandibular gland presented normal aspects for these organs, without significant characteristics related to inflammatory infiltrates in any of the 6 samples tested in their respective groups. El objetivo del estudio fue evaluar algunas caracteristicas biologicas y de toxicidad provenientes de las formulaciones basicas de dentifricos que contienen silice en su composicion y compararlos con dos dentifricos disponibles comercialmente que tambien presentan silice. El analisis hematologico no mostro diferencias entre los grupos evaluados. Los niveles de trombocitos presentados por los grupos fueron tambien normales. La transaminasa gluamico pirubica se mostro un aspecto normal en 5 de los grupos estudiados, asi como en el grupo control. La transaminasa glutamico oxaloacetica en uno de los grupos tuvo un pequeno incremento. En relacion a la orina, 4 grupos presentaron leucocitosis urinaria significativamente mayor que el grupo de control. La evaluacion histologica del higado, estomago, rinones y glandulas submandibulares se presento con aspecto normal, sin presencia de infiltrado inflamatorio.