A virtual plant for integrated continuous manufacturing of a carfilzomib drug substance intermediate. Part 1: CDI-promoted amide-bond formation

Elçin Içten,Andrew J. Maloney,Matthew G. Beaver,Dongying Erin Shen,Xiaoxiang Zhu,Lauren R. Graham,Jo Anna Robinson,Seth Huggins,Ayman Allian,Roger Hart,Shawn D. Walker,P.A. Rolandi,Richard D. Braatz

A virtual plant for integrated continuous manufacturing of a carfilzomib drug substance intermediate. Part 1: CDI-promoted amide-bond formation

2020

Elçin Içten
Andrew J. Maloney
Matthew G. Beaver
Dongying Erin Shen
Xiaoxiang Zhu
Lauren R. Graham
Jo Anna Robinson
Seth Huggins
Ayman Allian
Roger Hart
Shawn D. Walker
P.A. Rolandi
Richard D. Braatz

This manuscript details process characterization efforts and the development of corresponding process models to inform a process control strategy to produce a carfilzomib drug substance intermediat...

Keywords:

virtual plant
Drug
Process control
Chemistry
continuous manufacturing
Process modeling
Organic chemistry
Carfilzomib
Peptide bond

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