ECOG multiple myeloma (MM) clinical trial (CT) accrual performance evaluation utilizing the NCITrial Complexity and Elements Scoring (NCI-TCES) and the NCI Myeloma Steering Committee Accrual Working Group (NCI MYSC AWG) scoring models.

8600 Background: Accrual to NCI CTs is often slower than planned and at times mandating premature closure resulting in loss of valuable resources and delay of scientific progress. The NCI MYSC AWG identified 10 barriers to accrual (BtA) to MM CTs (reimbursement, competing treatment options, treatment at NCI designated sites only, etc.). The NCI-TCES was created to objectively assess CT complexity (study arms, registration/randomization steps, treatment and follow-up complexity and duration, etc.). We evaluated the accrual performance of all previously conducted and currently ongoing (as of 12-31-2013) therapeutic ECOG MM CTs (excluding transplant) utilizing these tools. Methods: The planned and actual accrual, duration of open enrollment and accrual per month of each selected CT was determined. The NCI-TCES model was applied to each CT and a total score calculated (range 0-18). The 10 NCI MYSC AWG BtA were reviewed as it concerns their relevance for each selected CT and described as unlikely (0), possibly...