Personal Exposure to Fine Particulate Matter and C- Reactive Protein among Patients with Periodontosis

The association between particulate matter (PM) and cardiovascular effects among patients with cardiopulmonary diseases has been well-documented in previous studies. It is still unknown whether patients with periodontosis are vulnerable to short-term PM exposure. We conducted a cross-sectional study on two panels of adult subjects, 30 adult patients with periodontosis and 30 healthy adults, in order to evaluate whether fine particulate matter (PM2.5) was associated with high-sensitivity C-reactive protein (hs-CRP) among patients with periodontal disease. We repeated collected each subjects’ blood samples, measured hs-CRP and monitored 12-hour average (0800-2000 hours) personal PM2.5 exposure four times during 2012. We used mixed-effects models to estimate the association between PM2.5 and hs-CRP, adjusted for cardiovascular risk factors. We found a 10 µg/m3 increase in PM2.5 was associated with 3.42% (95%CI: 1.5, 3.3; p<0.001) increase in hs-CRP for the overall effect of personal PM2.5 exposure. The effec...