COMBINED WOUND HEALING ACTIVITY OF GYMNEMA SYLVESTERE AND TAGETES ERECTA LINN

To screen the wound healing activity of carbopol gels prepared from hydro alcoholic extracts of Gymnema sylvestere (GE) and Tagetes erecta Linn. (TE) in excision wound model and burn wound models in albino mice. Formulations of the extracts was done in the form of gels of carbopol individually and also in combination in equal ratio. In excision and burn wound models, the so treated animals showed significant reduction in period of epithelization and wound contraction and combined gel showed accelerated wound healing activity may be because of synergism. The enhanced wound healing activity of hydro alcoholic extracts may be due to free radical scavenging action and the phytoconstituents (flavonoids) present in it which either due to their individual or additive effect fastens the process of wound healing. Presence of flavonoids in alcoholic extracts was confirmed by phytochemical investigation and TLC methods.