COMPARISON BETWEEN COMBINATION OF RISPERIDONE AND HALOPERIDOL THERAPY WITH COMBINATION OF RISPERIDONE AND CHLORPROMAZINE THERAPY ON CLINICAL SYMPTOM IMPROVEMENT OF SCHIZOPHRENIA

Background: Risperidone, haloperidol and chlorpromazine are antipsychotics that can easily be found in most hospitals but its use in combination does not yet have strong evidence especially to clinical symptom of schizophrenia patients. Objectives: This research aimed to know the difference between the combination of risperidone and haloperidol therapy with a combination of risperidone and chlorpromazine therapy on clinical symptom improvement of schizophrenia. Materials and methods: It used observational analytic design with prospective cohort approach. 30 subjects were divided into 2 groups where on 15 subjects who received a combination of risperidone and haloperidol therapy and 15 subjects received a combination of risperidone and chlorpromazine therapy. Improvement of clinical symptoms rated by Positive and Negative Syndrome Scale – Excited Component (PANSS-EC) instrument at baseline and on the 1st day, on the 2nd day and on the 3rd day of therapy and Positive and Negative Syndrome Scale – Excited Component (PANSS) instrument at baseline and on the 1st week, on the 2nd week on the 4th week, and on the 6 th week of therapy. Results: The results showed that the decrease of PANSS-EC score was significant in both groups since the 1st day, the 2nd day and the 3rd day (p