S1675 Crosstalk Between Notch and Toll Signaling in Murine Colitis

loss of colonic crypts with inflammatory mononuclear cell infiltration. In contrast, WT colons had well preserved colonic architecture with inflammatory cell infiltration. Conclusions: We have shown that IAP-KO mice were unable to recover from DSS-induced chronic colitis compared with wild-type. The lack of weight-loss may be due to the enhanced absorption of dietary fat known to occur in the IAP-KO mice. Our results suggest that the gut mucosal defense factor, IAP, may play an important role in protecting the host against effects of intestinal injury/inflammation.