Therapy-related T-cell lymphoblastic lymphoma and inv(11)(q21q23) following acute promyelocytic leukemia chemotherapy
2011
Acute promyelocytic leukemia (APL) with the unique t(15;17) translocation has a high complete remission and disease-free survival rates following chemotherapy with all-trans-retinoic acid. Chemotherapy complications including secondary malignancies are rare. In this report we present therapy-related T-lymphoblastic lymphoma following APL treatment. The bone marrow analysis showed MLL and MAML2 genes rearrangement that can explain the molecular basis for the lymphoma development.
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