Glucose metabolism in the brain in LMNB1‐related autosomal dominant leukodystrophy

Objective LMNB1‐related autosomal dominant leukodystrophy is caused by an overexpression of the protein lamin B1, usually due to a duplication of the LMNB1 gene. Symptoms start in 5th to 6th decade. This slowly progressive disease terminates with death. We studied brain glucose metabolism in this disease using 18F‐fluorodeoxyglucose positron emission tomography (PET).